{"product_id":"c-peptide-check-1-quantitative-determination-of-c-peptide-in-whole-blood-plasma-or-serum-samples","title":"C-Peptide-CHECK-1 Quantitative determination of C-Peptide in whole blood, plasma or serum samples","description":"\u003cp\u003eHuman C-Peptide, a 31 aminoacid residue peptide having a\nmolecular mass of approximately 3 000Da. (1) connects\nInsulin’s A and B chains within the proinsulin molecule (2, 3).\nProinsulin is subsequently cleaved enzymatically into the\nbeta-cells of the pancreas leading to an equimolar release of\ninsulin and C-Peptide into the blood stream (4).\nThe degradation rate of C.Peptide in the body being slower\nthan that of insulin (half life of 20-30 minutes, compared with\nthe half-life of insulin of just 3-5 minutes), its measurement is\na more stable indicator of insulin secretion and beta-cell\nfunction (5).\nDue to its relative metabolic inertness, the C-Peptide levels in\nperipheral venous blood are about 5-6 times greater than\ninsulin levels. In addition, another advantage of C-Peptide\nassay is its ability to distinguish endogenous from injected\ninsulin. Therefore, a very low C-Peptide concentration\nconfirms Type 1 diabetes and insulin dependence while\nelevated C-Peptide levels are associated to Type 2 diabetes or\nto the increased B-cell activity observed in insulinomas (6, 7,\n8).\nThe C-Peptide-CHECK-1 test is a rapid quantitative assay for\nthe detection of C-Peptide in serum, plasma or whole blood.\nThe method employs a unique combination of monoclonal-\ngold conjugate and monoclonal solid phase antibodies to\nidentify C-Peptide in the test samples with a high degree of\nspecificity.\nAs the test sample flows through the absorbent device, the\nlabelled antibody-gold conjugate binds to the C-Peptide\nforming an antibody-antigen complex. This complex binds to\nthe anti- C-Peptide antibody in the positive reaction zone (T)\nand produces a pink-rose colour band.\nIn the absence of C-Peptide, there is no line in the positive\nreaction zone (T). The reaction mixture continues flowing\nthrough the absorbent device past the reaction zone (T) and\ncontrol zone (C).\nDepending on the C-Peptide concentration level, different\nlines of different intensities will appear on the reading window\nallowing the quantitative measurement of C-Peptide when\nused in combination with the VEDALAB’s readers\nEASYREADER® or EASYREADER+®.\u003c\/p\u003e\n\n\u003cp\u003eEach kit contains\u003c\/p\u003e\u003col\u003e\n\u003cli\u003eC-Peptide-CHECK-1reaction devices: 10 20\u003c\/li\u003e\n\u003cli\u003eDisposable plastic pipettes: 10 20\u003c\/li\u003e\n\u003cli\u003eDiluent in a dropper bottle: 2.5mL 5mL\u003c\/li\u003e\n\u003cli\u003eInstruction leaflet: 1 1\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Veda Lab","offers":[{"title":"Default Title","offer_id":56011392319753,"sku":"P-ER-C-PEPTIDE","price":116.81,"currency_code":"EUR","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0948\/2443\/1881\/files\/QUANTITATIVE-TESTS.jpg?v=1755092643","url":"https:\/\/b2b.vital20.com\/products\/c-peptide-check-1-quantitative-determination-of-c-peptide-in-whole-blood-plasma-or-serum-samples","provider":"Vital20 B2B store","version":"1.0","type":"link"}