FSH-CHECK-1 Quantitative determination of Follicle Stimulating Hormone (FSH) in whole blood, plasma or serum samples

The follicle stimulating hormone (FSH) is a glycoprotein hormone produced in the anterior pituitary in response to the gonadotropin releasing hormone from the hypothalamus. It promotes the development and maintenance of gonadal tissues which synthetise and secret the steroid hormones. In females, FSH is responsible for the ovum maturation during the menstrual cycle. The level of FSH is controlled through a negative feed-back mechanism by estradiol and progesterone. The determination of FSH in conjunction with LH is useful in detecting amenorrhea or anovulatory menstrual cycles. Furthermore, FSH can be used in diagnosis of polycystic ovary syndrome, psychogenic amenorrhea, pituitary tumors and ectopic tumor production. Follow-up of patients with choriocarcinoma and hydatidiform mole. In males, FSH stimulates the production of sperm and testosterone. FSH and LH measurement in males are useful in detection of primary and secondary testicular failures. FSH values are up to 15 IU/L for adult males and 200 IU/L for post menopausal females. Menstruating females have a mid cycle peak. The FSH-CHECK-1 is a rapid quantitative assay for the specific detection of FSH in whole blood, plasma and serum samples. As the test sample flows through the absorbent device, the labelled antibody-dye conjugate binds to the FSH forming an antibody-antigen complex. This complex binds to the anti FSH antibody in the reaction zone (T) and produces a pink-rose coloured band. In the absence of FSH, there is no line in the reaction zone (T). The mixture continues to flow through the absorbent device past the reactive zone (T) and control zone (C). Unbound conjugate binds to the reagents in the control zone (C), producing a pink-rose coloured band, demonstrating that the reagents are functioning correctly.

Each kit contains

1. FSH CHECK-1 reaction devices : 10 20
2. Disposable plastic pipettes : 10 20
3. Diluent in a dropper bottle : 2.5mL 5mL
4. Instruction leaflet : 1 1
5. Controls (Optional): Positive control ref. V6000 and Negative control ref. V6001: a freeze-dried preparation of a non-infectious compound in diluted human serum, tested and found negative for anti-HIV, anti-HCV and HBs antigen, containing 0.05 % sodium azide is optionally available as a positive and negative control (1x 0.25 mL). The concentration range is indicated on the vial label.